Talk with your doctor about your health history and discuss your risks with Prolia treatment. * For more information about this side effect, see Side effect specifics below. Serious side effects of Prolia that have been reported include: For most people, Prolias side effects are mild and go away after a few days to a few weeks. With low BMD your bone tissues have less mineral, which means they become weaker. If youve been diagnosed with osteoporosis, your doctor may discuss Prolia with you. Low blood calcium level. For more information, you can refer to the drugs prescribing information. Prolia may cause several side effects. If youre pregnant or breastfeeding, or considering either, talk with your doctor. To learn how Prolia and Tymlos are alike and different, see this comparison. If you keep this medicine at home, store it in the original carton in a refrigerator. The ADA also provides recommendations to help your dentist in reducing your risk for these side effects while youre taking Prolia. You may need to stop using the medicine for a short time. Below are commonly used dosages, but the dosage you receive will be determined by your doctor. Drug class: miscellaneous bone resorption inhibitors. if you are taking medicine that lower your blood calcium levels. Prolia was the right choice for me because it worked for me and it was 1 shot every 6 months. The risk is highest in people with cancer, blood cell disorders, pre-existing dental problems, or people treated with steroids, chemotherapy, or radiation. Last updated on Feb 8, 2023. They can explain the risks and benefits of this drug. They might also recommend physical therapy, massage therapy, or using a heating pad. Studies of Prolia didnt report weight gain as a side effect of the drug. Prolia is a prescription medicine used to treat bone loss in men who are at high risk for fracture receiving certain treatments for prostate cancer that has not spread to other parts of the body. Also, its important to brush and floss your teeth regularly while youre using Prolia. 2,4. pain in bones and muscles, including back, arm, and leg pain, pain or swelling in the thigh or groin area. WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health. You may need to have a dental exam before you begin treatment with Prolia. Call your doctor for medical advice about side effects. High cholesterol itself doesnt cause any symptoms. You may report side effects to FDA at 1-800-FDA-1088. Generic name: denosumab (Prolia) [den-OH-sue-mab] If you have a male* sexual partner, they should use birth control during this time as well. Lifestyle changes that can help improve cholesterol levels include exercising regularly and eating a healthy diet. Some rare side effects of Prolia can be serious and need medical attention. Prolia 60 mg/1 mL in a single-dose prefilled syringe (medicine). Your doctor may also have you take certain supplements that contain calcium and vitamin D while youre receiving Prolia. A biologic drug is made from parts of living organisms. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. Tingling wasnt specifically reported as a side effect of Prolia in clinical trials. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. Side effects that you should report to your doctor or health care professional as soon as possible: Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome): This list may not describe all possible side effects. You can also visit the Prolia manufacturers website to see if they have support options. It can have some side effects, but these may depend on who uses it. MNT is the registered trade mark of Healthline Media. Prolia contains the same medicine as XGEVA (denosumab). Get useful, helpful and relevant health + wellness information, 9500 Euclid Avenue, Cleveland, Ohio 44195 |, Important Updates + Notice of Vendor Data Event, low levels of calcium or Vitamin D in the blood, an unusual reaction to denosumab, other medicines, foods, dyes, or preservatives, medicines that lower your chance of fighting infection, steroid medicines like prednisone or cortisone, allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue, signs and symptoms of infection like fever or chills; cough; sore throat; pain or trouble passing urine, signs of low calcium like fast heartbeat, muscle cramps or muscle pain; pain, tingling, numbness in the hands or feet; seizures. Your risk for having more than 1 broken bone in your spine is increased if you have already had a broken bone in your spine. Prolia This aids in keeping your calcium level within the recommended range. (2022). These side effects may include: Its not known what percentage of people in clinical trials developed dental or jaw-related side effects. Prolia can also cause bones to not form correctly and reduced growth in a fetus. Specifically, Prolia works by blocking a protein called RANK. Some side effects of Prolia may go away on their own within a few days or weeks after starting treatment. Prolia is also used to treat glucocorticoid-induced osteoporosis in men and women at high risk of bone fracture. Be sure to talk with your doctor about your health history before you take Prolia. And theyll recommend if its the best option for your condition. They may recommend ways to ease your symptoms and determine whether you should keep taking Prolia. Theyll need to confirm that you arent pregnant. Prolia is used to treat osteoporosis in women after menopause and in men, and in people who are taking corticosteroids for 6 months or more. Patients in the study may take other drugs besides Prolia and Calcium. They can also include swelling of your tongue, mouth, or throat, which can cause trouble breathing. (Vitamin D helps your body absorb calcium.) Biosimilars usually cost less than brand-name drugs. If you have low calcium levels, you should not take Prolia. Serious side effects from Prolia can occur, but they arent common. Sciatica is described as a shooting pain that travels from the lower back down a leg. These medications have different active ingredients and they belong to different groups of drugs. Denosumab is contraindicated in women with hypocalcaemia. to treat osteoporosis in males* and in females* whove gone through, to treat osteoporosis caused by long-term use of, metabolic bone disease, such as Hajdu-Cheney syndrome and juvenile. So, if you want to stop taking Prolia, talk with your doctor. (A low blood calcium level is a possible side effect of Prolia.). Whats the Connection Between Estrogen and Osteoporosis? Hair loss with Prolia is rare, and whether Prolia is responsible for this effect isnt known. You should not receive Prolia if you are allergic to denosumab, or if you 2023 Healthline Media UK Ltd, Brighton, UK. You may also want to do some research on your own. Prolia and Xgeva both contain the active drug denosumab, but they are not approved to treat all of the same conditions. Symptoms of a severe allergic reaction can include swelling under your skin, typically in your eyelids, lips, hands, or feet. It is often used in osteoporosis. These side effects include: Your risk for these serious side effects may be higher if youre older and have certain dental procedures. For more information about how these medications compare with each other, ask your doctor. Bone density decreases with time, and some people have a risk of developing weak or brittle bones. NOTE: This sheet is a summary. Theyll also discuss with you how to lower your risk for fractures by adding other treatments or making certain lifestyle or diet choices. If youre able to become pregnant, your doctor will have you take a pregnancy test before you start Prolia treatment. Patient testimonials represent individual experiences with Prolia. But tingling may be a symptom of side effects such as sciatica and hypocalcemia. These types of medications come in forms that are taken by mouth and forms that are given by injection. You may have questions about Prolia and your treatment plan. BMD was increased by 8.8% at the lumbar spine, 6.4% at the total hip, and 5.2% at the femoral neck in trials that measured BMD after three years of treatment with Prolia. A special MedGuide will be given to you before each treatment. Its recommended that calcium and vitamin D supplements be taken Over time, Prolia helps to improve the density and strength of your bones by slowing bone loss. In addition, you should use effective birth control while youre taking Prolia. Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. Dizziness from Prolia is usually mild and may go away on its own within a few days or weeks. See additional information. Mild side effects of Prolia that have been reported include: Mild side effects of many drugs may go away within a few days or a few weeks. With osteopenia, your bone mineral density (BMD) is lower than usual. Hair loss with Prolia was reported after the drugs initial studies were done and it was approved for use. Research has shown people who take Prolia are at an increased risk of serious infections leading to hospitalizations, including endocarditis and serious infections of the skin, abdominal, urinary tract, and ear. Osteoporosis is a condition that causes your bones to become thin and weak. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Its important to discuss all your concerns with your doctor. The risk is real, but rare. You may wonder how Prolia compares to the medication Zometa. Be sure to talk with your doctor about which medication is right for you. Ask your doctor about your own risk. If youd like a detailed comparison of Prolia versus Boniva, view this article. Osteoporosis is a condition that weakens your bones, making them more susceptible to fractures. If you are a healthcare professional, click "I Agree" to continue. Other studies have examined the risk of damage to jaw tissue with the use of bisphosphonates, one type of medication commonly used to treat osteoporosis. Use of the term male in this article refers to sex assigned at birth. 2023 Healthline Media LLC. More common side effects in females* who received Prolia for osteoporosis after menopause included: More common side effects in males* who received Prolia for osteoporosis included: More common side effects in people who received Prolia for osteoporosis due to drugs called glucocorticoids included: More common side effects in people who received Prolia to stop bone thinning due to certain cancer treatments included: For a complete list of all the side effects reported with Prolia, see the drugs prescribing information. The use of the eHealthMe site and its content is at your own risk. Prolia is a prescriptionmedicine used to treat bone loss in women who are at high risk for fracture receiving certain treatments for breast cancer that has not spread to other parts of the body. As you age, your BMD is reduced, and this may increase your risk for osteoporosis. Not getting enough calcium in your diet can lead to fragile, brittle bones that are more prone to fractures and disease. All rights reserved. Theyll likely suggest other treatment options for your condition. Advertising on our site helps support our mission. The conditions and factors to consider include: Upcoming dental procedures. My GP (not the doctor who treats my osteoporosis) wondered if my early complete hysterectomy (I havent taken estrace in 15 years) and high dosage of thyroid I must take daily, effect the absorption of calcium? To see a side-by-side comparison of Prolia and Fosamax, view this drug article. Theres no information available to know whether Prolia is passed into breast milk or if its safe to take while breastfeeding. Talk to your health care professional or pharmacist for more information. You might wonder how Prolia and the drug Xgeva compare. If you plan to drink alcohol while using Prolia, ask your doctor how much is safe to drink. No one in clinical trials of Prolia had to stop taking the drug due to dizziness. If you develop a side effect while taking Prolia and want to tell the FDA about it, visit MedWatch. (BMD is a measurement of the amount of minerals such as calcium in your bones.) Ask your plan if they cover the drug, and what the cost will be for you. It may also be higher if you have dental work done while youre taking Prolia. And in my mind, that's no different than scheduling a visit to the dentist twice a year. Bring someone with you to your appointment if doing so will help you feel more comfortable. WebAdults ages 19 through 50 should not get more than 2,500 mg calcium total per day (including food and supplements). If your dizziness doesnt go away or becomes severe, talk with your doctor. Prolia Injection (Denosumab): Uses & Side Effects Copyright 2023 Elsevier Inc. All Rights Reserved. In rare cases, dental and jaw-related side effects have been reported with Prolia treatment. Your dentist may have you use a chlorhexidine mouth rinse before and after surgery to reduce your risk for jaw-related side effects. If you notice any tooth or jaw pain, or sensitivity while using Prolia, talk with your doctor or dentist right away. Special care may be needed. The study uses data from the FDA. If youd like more information about Prolia use during pregnancy or while breastfeeding, talk with your doctor. Prolia may lower the level of calcium in your blood. Peripheral edema is a less common side effect that was reported in clinical studies of females* who received Prolia for osteoporosis after menopause. Prolia: Side Effects, Alternatives, How It's Administered, you can take. They can give you more details about this possible side effect and suggest ways to manage it. Women going through menopause have a higher risk of developing osteoporosis. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Prolia (denosumab) and Reclast (zoledronic acid) are injections that can be used to treat or prevent osteoporosis in postmenopausal women. This increases your risk for bone fractures. Call your doctor or go to your nearest emergency room right away if you have any symptoms of a serious allergic reaction, including low blood pressure (hypotension); trouble breathing; throat tightness; swelling of your face, lips, or tongue; rash; itching; or hives. Some people using Prolia have developed bone loss in the jaw, also called osteonecrosis of the jaw. Osteoporosis DENOSUMAB (den oh sue mab) slows bone breakdown. Because these reports happened after the studies, it isnt known for sure whether Prolia caused hair loss, or if it was due to another reason. Tell your doctor if you become pregnant. Call your doctor for medical advice about side effects. Since different people For women with osteoporosis after menopause at high risk for fracture. Yoga for Osteoporosis: 5 Beneficial Poses, Diet and Osteoporosis: Nutrients, Diet Tips, and More. If youre concerned about weight gain with Prolia, talk with your doctor. If you have serious side effects from Prolia, call your doctor right away. But its not clear how often this side effect occurred in clinical trials. Its a prescription drug thats used to treat osteoporosis and other forms of bone loss. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. Your doctor may have you take extra calcium and vitamin D while you are being treated with Prolia. So, your bones become weak and brittle. Learn more about the unique risk factors for osteoporosis in, Osteoporosis weakens bones, which leads to breaks in the hips, wrists, and spine. You should not breastfeed while using this medicine. They can suggest ways to help relieve these side effects. To learn more about this, see the How is Prolia administered? section below. low calcium level--muscle spasms or contractions, numbness or tingly feeling (around your mouth, or in your fingers and toes).
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